Search Results - neurosciences

8 Results Sort By:
Staircase Method for Optimized Therapeutic Hypothermia
Tech ID: lyd000931IntroductionTherapeutic hypothermia is used in patients suffering stroke, cardiac arrest, head trauma, subarachnoid hemorrhage, and in infants after hypoxic-ischemic injury. In several clinical trials published to date, therapeutic hypothermia has failed to show benefits commensurate with the benefit predicted from animal studies....
Published: 6/27/2017   |   Inventor(s): Patrick Lyden, Padmesh Rajput, Konrad Schlick, Mani Nezhad, Jessica Lamb
Keywords(s): Neurosciences
Category(s): Therapeutics/prophylactic, Device(s)
Visual Stimuli Plus Maze Test/Apparatus for the Detection of Visual Abnormalities in Rodent Models of Alzheimer's Disease
Tech ID: kor000977IntroductionCurrently, there are no effective treatments or feasible screening tools for early detection and monitoring progression of Alzheimer’s disease (AD).Current evidence indicates that amyloid-related changes likely occur 10-20 years prior to symptom manifestations, suggesting that they may be excellent biomarkers for...
Published: 6/15/2017   |   Inventor(s): Maya Koronyo, Yosef Koronyo, Keith Black
Keywords(s): Neurosciences
Category(s): Tool
Detection and Quantification of Brain Motion and Pulsatility - BrainPulse
Tech ID: ros000989IntroductionThe cyclic perfusion of the brain with arterial blood induces reflective movements of the brain tissue leading to predictable expansion and relaxation of the brain which can be termed ‘brain pulsations.’Brain injury leads to tissue density changes (‘swelling or congestion’) affecting the brain t...
Published: 12/6/2016   |   Inventor(s): Axel Rosengart
Keywords(s): Neurosciences
Category(s): Device(s)
Device for Advanced Functional Brain Monitoring With and Without Simultaneous Brain Fluid Drainage - Ventrode
Tech ID: ros000984IntroductionPlacing an external ventricular drain is often the first life-saving procedure indicated in many patients with moderate to severe brain injury or obstruction of brain fluid of various types. Surface electroencephalography (EEG) is then used to monitor patients with brain injury who are at a higher risk for seizure and...
Published: 12/6/2016   |   Inventor(s): Axel Rosengart, Ueli Rutishauser
Keywords(s): Neurosciences
Category(s): Device(s)
Using Dual GLP-1/GIP Receptor Agonists to Treat Brain Insulin Resistance, Mild Cognitive Impairment and Alzheimer’s Disease Dementia
Tech ID: tal000941IntroductionAlzheimer’s disease (AD) poses one of the great challenges to 21st century medicine. It is the 6th leading cause of death in the US and after more than a century since its discovery, there are still no clinically effective treatments for AD that substantially slow or stop its progression. If the current situation...
Published: 8/4/2016   |   Inventor(s): Konrad Talbot, Hoau-Yan Wang, Keith Black
Keywords(s): Neurosciences
Category(s): Therapeutics/prophylactic
A Model for Predicting Chronic Traumatic Encephalopathy (CTE)
A model for predicting chronic traumatic encephalopathy (CTE) Tech ID: ley000981IntroductionChronic traumatic encephalopathy (CTE) is a neurodegenerative condition that presents clinically as a composite syndrome of mood disorders, behavioral and cognitive impairment, which may come with or without sensorimotor impairment. This condition leads to p...
Published: 4/18/2016   |   Inventor(s): Eric Ley, Gretchen Thomsen
Keywords(s): Neurosciences
Category(s): Tool
Apo A-1 Milano for Alzheimer's Disease
Tech ID: sha482/059/470/400IntroductionApolipoprotein A-I (ApoA-I) is the major structural protein component of high-density lipoprotein (HDL). Apolipoprotein A-I Milano (ApoA-IM), a naturally occurring Arg173 to Cys mutant of ApoA-I, was found in a small number of inhabitants of a northern Italian town. Compared to the normal gene (apolipoprotein ...
Published: 12/21/2015   |   Inventor(s): Prediman Shah
Keywords(s): Gene Therapy, Neurosciences
Category(s): Therapeutics/prophylactic
Novel Blood Cell Biomarker for Late Onset Alzheimer's Disease (AD)
Tech ID: whe000921IntroductionLate onset Alzheimer’s disease (LOAD) is the most common neurodegenerative disorder of aging, affecting 5.4 million patients annually in the US alone. It is a progressive, incurable disease and has remained a diagnostic and therapeutic challenge so far. The initial causal factors of this disease are still unclear...
Published: 11/30/2015   |   Inventor(s): Christopher Wheeler
Keywords(s): Neurosciences
Category(s): Diagnostic