Search Results - shlomo melmed

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PTTG Knockout Rodent as a Model to Study Mechanisms for Various Physiological Phenomena, including Diabetes
Tech ID: mel000052IntroductionPituitary tumor transforming gene (PTTG) is a recently observed oncogene isolated from pituitary tumor growth hormone-secreting cells. Despite all of the research and resources applied to understanding the role of PTTG in cell cycle control and the pathogenesis of numerous disease conditions, including tumorigenesis, t...
Published: 8/5/2016   |   Inventor(s): Shlomo Melmed, Zhiyong Wang
Keywords(s): Research
Category(s): Tool
Use of Tyrosine Kinase Inhibitors for Treatment of Cushing's Disease and Hypercortisolism
Tech ID: fuk000432IntroductionCushing's Disease is a condition in which the pituitary gland releases excessive adrenocorticotropic hormone (ACTH) as a result of an adenoma arising from the ACTH-secreting cells in the anterior pituitary. ACTH-secreting pituitary adenomas lead to hypercortisolemia and cause significant morbidity and mortality. No dru...
Published: 8/4/2016   |   Inventor(s): Hidenori Fukuoka, Shlomo Melmed
Keywords(s): Endocrinology
Category(s): Therapeutics/prophylactic
Method for Drug Screening and Characterization by Calcium Flux Analysis
Tech ID: ben000015IntroductionIon channels participate in, and regulate, cellular processes as diverse as the generation and timing of action potentials, energy production, synaptic transmission, and secretion of hormones and the contraction of muscles. In fact, many drugs exert their specific effects via modulation of ion channels. One example of ...
Published: 12/17/2015   |   Inventor(s): Anat BeN-Shlomo, Shlomo Melmed, Kolja Wawrowsky
Keywords(s): Drug Discovery/Screening, Research
Category(s): Tool