Detection of an Occurrence of a Cardiac Arrhythmia Based on Sympathetic Neural Discharges

Tech ID: che000130

 

Introduction
Sudden cardiac death (SCD) is a major public health problem that accounts for more than half of all cardiovascular deaths. SCD takes the lives of approximately 450,000 people in the United States each year, more than lung cancer, breast cancer, stroke, and AIDS combined. Most cases of SCD are due to ventricular arrhythmias and there is often an element of underlying ischemic heart disease. Different treatment options exist for SCD. The most common treatment includes implantable cardiac defibrillators (ICD) and drug therapy. Current ICD technology, however, provides for the detection and recognition of an arrhythmia based on the sensed heart rate once it has already started. This leaves very little time to protect the individual from death resulting from SCD. Although there have been several attempts at developing new technology for predicting the onset of a cardiac arrhythmia, many of these methods and systems appear to rely primarily on events occurring within the heart, such as sensed heart rate and electrocardiography (ECG).


Technology Description
To fulfill the demand for a better method for the detection and recognition of an arrhythmia, Dr. Chen from Cedars-Sinai Medical Center has developed a method and device to monitor the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, and/or any other sympathetic nerve identified as having an influence over the heart rate of a patient. To do so, the sympathetic neural discharges of a patient is monitored using a sensor implanted in the stellate ganglia, the thoracic ganglia, and/or any other sympathetic nerve for which the rate of neural discharge influences the heart rate in a patient. In case the nerve activity increases, a radio-transmitted signal is then produced indicating the likely onset of an arrhythmia, myocardial ischemia, and/or other diseased condition of the heart associated with elevated sympathetic nerve discharges. The system described herein may be incorporated into any number of implantable medical devices including, but not limited to, implantable cardiac rhythm management systems such as pacemakers, cardioverters, defibrillators, and the like. The system may also be incorporated in external unimplanted devices of the same sort, as well as in external monitors, programmers and recorders.


Stage of Development
Animal data


Advantages/Novelty
This method relies on elevated sympathetic nerve discharges to detect an occurrence of a cardiac arrhythmia. This goes further than current ICD technology which is based on the sensed heart rate once it has already started and which leaves very little time to protect the individual from death resulting from SCD.


Application
Detection and recognition of an arrhythmia


Intellectual Property
•       US patent 7266410 granted;
•       US patent 7725178 granted;
•       US patent 8744571 granted.

Patent Information:
Category(s):
Device(s)
For Information, Contact:
Julien Brohan
julien.brohan@cshs.org
Inventors:
Peng-Sheng Chen
Shengmei Zhou
Keywords:
Cardiovascular