Magnetic Resonance Black-Blood Thrombus Imaging in Detection of Cerebral Venous Thrombosis

Tech ID: yan0000942



Cerebral venous thrombosis (CVT) is a form of stroke that usually affects young individuals. During the past decade, better diagnosis and treatments have improved the outcome of CVT. However, CVT is frequently unrecognized and the average delay from the onset of symptoms to diagnosis is about one week.


Diagnosis of CVT typically relies on a combination of different imaging modalities, such as computed tomography venography, magnetic resonance venography, and conventional X-ray angiography. These methods assess CVT indirectly by imaging venous flow perturbation caused by thrombus. Despite existing methods to diagnose CVT, given the variation in venous anatomy, it is sometimes difficult to exclude CVT with existing noninvasive imaging modalities. New systems and methods for magnetic resonance imaging could increase the accuracy of diagnosis of CVT.


One general solution to these limitations is the direct visualization of the thrombus itself. Magnetic resonance direct thrombus imaging, as a non-contrast-enhanced T1-weighted imaging method, has gained broad interest. However, this technique also suffers drawbacks such as insensitivity to chronic thrombus. There is a need in the art for improved systems and methods for detecting CVT.


Technology Description

Dr. Li, et al. from Cedars-Sinai Medical Center developed a novel magnetic resonance black-blood thrombus imaging technique (MRBTI) for the detection and quantification of CVT.


The technique uses:

• 3-dimensional (3D) variable flip angle turbo spin echo to visualize thrombi; and

• T1 weighted image contrast and isotropic sub-millimeter spatial resolution for accurate detection and staging of thrombi


Stage of Development

Clinical data



By using this imaging technique, CVT can be isolated from the surrounding tissues including luminal blood flow and the vessel wall, and thus the location and size of CVT can be readily appreciated.



Diagnosis of CVT


Intellectual Property

• U.S. Non-provisional Patent Application filed - 15/015,904 



• Yang et al. Early Detection and Quantification of Cerebral Venous Thrombosis by Magnetic Resonance Black-Blood Thrombus Imaging. Stroke. 2016 Feb; 47: 404-409. Link


Patent Information:
For Information, Contact:
Julien Brohan
Qi Yang
Zhaoyang Fan
Debiao Li
Xunming Ji